Pharmacokinetics of cefoperazone, moxalactam, cefotaxime, trimethoprim and suiphamethoxazole in experimental meningitis

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Abstract
The pharmacokinetics of cefoperazone, moxalactam, cefotaxime, trimethoprim and sulphamethoxazole in cerebrospinal fluid (CSF), after a single intravenous dose, were studied in rabbits. The β-lactam antibiotics penetrated poorly into the CSF of rabbits with uninflamed meninges while trimethoprim and sulphamethoxazole penetrated well. In the presence of meningitis, however, the CSF concentrations of all except sulphamethoxazole increased by two- to threefold. The half-lives of cefoperazone and moxalactam in CSF, measured by a bioassay, were notably prolonged by meningeal inflammation when compared to the other antimicrobials studied. All these agents reached concentrations in CSF that were above the MICs for the majority of Enterobacteriaceae, indicating their potential value in treatment of Gram-negative bacillary meningitis.

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