Primary Cortisol Resistance: A Family Study
- 1 June 1983
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 56 (6) , 1243-1245
- https://doi.org/10.1210/jcem-56-6-1243
Abstract
Primary cortisol resistance is an autosomal disease characterized by increased plasma cortisol concentration and high urinary free cortisol, resistance to adrenal suppression by dexamethasone, and the absence of clinical stigmata of Cushing's syndrome. The proband with the severe form had hypertension and hypokalemic alkalosis. In subjects with a less severe resistance to cortisol, there are no clinical abnormalities and the condition is revealed only by detailed examination of several parameters of cortisol secretion. (J Clin Endocrinol Metab56: 1243, 1983)Keywords
This publication has 3 references indexed in Scilit:
- Primary cortisol resistance in man. A glucocorticoid receptor-mediated disease.Journal of Clinical Investigation, 1982
- An H-2 linked difference in the binding of dexamethasone to murine hepatic cytosol receptor a possible role of endogenous modifier(s)Biochimica et Biophysica Acta (BBA) - General Subjects, 1981
- Spontaneous Hypercortisolism without Cushing's SyndromeJournal of Clinical Endocrinology & Metabolism, 1976