VASCULAR NEPHRITIS AND HYPERTENSION

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Abstract
In recent years, medical interest has been centered on the problem of hypertension. Although it was in 1827 that Bright connected the condition of the kidney with blood pressure and there have been frequent observations of the relation of cardiac hypertrophy to surgical renal disease which date back as far as 1835, it remained for Goldblatt's1work on experimentally produced hypertension in dogs and monkeys to reawaken interest in the subject and open a new and profitable approach to experimentation. Renal ischemia may be produced in a variety of ways. In addition to the classic experiments of Goldblatt and the recording of numerous instances of hypertension in polycystic kidneys and hydronephrosis, one must consider arteriosclerotic plaques of the renal artery and pyelonephritis as causal factors. Blackman2examined fifty cases of "essential" hypertension and fifty control cases without hypertension and found arteriosclerotic plaques causing reduction in the lumens of

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