Two New Furanoditerpenes from Saururus chinenesis and Their Effects on the Activation of Peroxisome Proliferator-Activated Receptor γ
- 16 March 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 65 (4) , 616-617
- https://doi.org/10.1021/np010440j
Abstract
Two new acyclic furanoditerpene compounds, saurufuran A (1) and B (2), were obtained from the root of Saururus chinensis, and their structures were elucidated by means of 1D and 2D NMR spectroscopic analyses. Saurufuran A (1) is effective on the activation of peroxisome proliferator-activated receptor γ (PPARγ) with an EC50 value of 16.7 μM; however, saurufuran B (2), with an EC50 value of >100 μM, weakly activated the PPARγ.Keywords
This publication has 8 references indexed in Scilit:
- PPAR-γ agonists: therapeutic role in diabetes, inflammation and cancerTrends in Pharmacological Sciences, 2000
- New approaches in the treatment of type 2 diabetesCurrent Opinion in Chemical Biology, 2000
- Two antifeedant lignans from the freshwater macrophyte Saururus cernuusPhytochemistry, 2000
- Peroxisome proliferator-activated receptors: three isotypes for a multitude of functionsCurrent Opinion in Biotechnology, 1999
- A Human Peroxisome‐Proliferator‐Activated Receptor‐γ is Activated by Inducers of Adipogenesis, Including Thiazolidinedione DrugsEuropean Journal of Biochemistry, 1996
- Asiaticusin A and B, Novel Prenylated Phenolics fromBoletinus asiaticusandB. paluster(Boletaceae) FungiBioscience, Biotechnology, and Biochemistry, 1996
- 15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγCell, 1995
- Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferatorsNature, 1990