LIVER FUNCTION IN HYPERTHYROIDISM AS DETERMINED BY THE HIPPURIC ACID TEST

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Abstract
6 g. sodium benzoate by mouth normally produces 3 g. hippuric acid in the urine in 4 hrs. and this was a moderately satisfactory test for detn. of parenchymatous hepatic damage; its simplicity and low cost is an advantage. 148 cases of clinical hyperthyroidism were tested (1) on day of admission, (2) day prior to operation and (3) 6th or 7th postoperative day. A table of hippuric acid excretion was given. The lowering of blood cholesterol and the lowering of serum proteins of blood with an alteration of albumin-globulin ratio was found to be related to liver damage. The A. found an apparent relationship between level of hippuric acid and blood cholesterol but none between it and total serum protein. In hyperthyroidism digitalis was toxic to the liver. A high CH and low fat diet in hyperthyroidism and glycine increased strikingly the amt. of excretion of hippuric acid.

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