Aspirin and ultraviolet light-induced erythema in man

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Abstract
In a double-blind crossover study orally administered aspirin buffered with magnesium aluminum hydroxide significantly reduced ultraviolet ligh-induced erythema 10 adult male subjects when compared with magnesium aluminum hydroxide used as a placebo. This effect was most noticeable at 4 and 6 hr. postirradiation but could be detected at 24 hr. Of the 4 subjects who complained of itching, aspirin relieved this symptom. The amount of aspirin taken (3.6 g per day) was within the usual therapeutic dose. The mchanism of this effect of aspirin is not known. A possible mechanism of action could be stablilizing lysosomes and the inhibition of kinins or enzymes.

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