ALKALOIDS OF THALICTRUM .21. ISOLATION AND CHARACTERIZATION OF ALKALOIDS FROM ROOTS OF THALICTRUM-PODOCARPUM

  • 1 January 1977
    • journal article
    • research article
    • Vol. 40  (4) , 384-394
Abstract
Thirteen alkaloids, hernandezine, thalidezine, N-desmethylthalidezine, isothalidezine, thalistyline, thalistyline methodiiodide, N-desemethylthalistyline, berberine, columbamine, jatrorrhizine, palmatine, thalifendine, magnoflorine and the artifact, 8-trichloromethyldihydroberberine were isolated from roots of T. podocarpum Humb. Oxyberberine and thaliglucinone were obtained in very minor amounts and identified by TLC. Of these compounds, N-desmethylthalidezine and isothalidezine are new bisbenzylisoquinoline alkaloids. Sucrose was isolated from the alcoholic extract. Hernandezine, thalistyline, thalidezine, thalistyline methodiiodide and N-desmethylthalistyline apparently possessed antimicrobial activity against Mycobacterium smegmatis at concentrations of 100 .mu.g/ml or less.

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