Plasma and Urine Cyclic Guanosine 3′:5′-Monophosphate in Disseminated Cancer

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Abstract
Plasma and 24-h urinary cyclic[c]AMP and cGMP were measured by radioimmunoassay in 12 normal subjects, 33 patients with 6 types of non-neoplastic disease (cholelithiasis, peptic ulcer, coronary heart disease, hypertension, regional ileitis and cirrhosis), and 34 patients with 5 types of disseminated neoplastic disease (acute myelocytic leukemia, Hodgkin''s disease, and metastatic cancer of the lung, colon, and breast). In patients with non-neoplastic disease, cyclic nucleotide values in plasma and urine did not differ significantly (P > 0.05) from those in normal subjects. In patients with disseminated cancer, cyclic AMP values in plasma and urine likewise did not differ significantly from those in normal subjects. Plasma cGMP was significantly elevated in all 5 types of cancer patients, and urinary cGMP was significantly elevated (5 times the normal mean) in patients with acute myelogenous leukemia and Hodgkin''s disease.