Recovery of Decreased Ability of Peripheral-Blood Mononuclear Cells from Chronic Renal Failure to Produce Interleukin-1α and β after Renal Transplantation
- 1 January 1991
- journal article
- research article
- Published by S. Karger AG in Nephron
- Vol. 58 (4) , 450-455
- https://doi.org/10.1159/000186478
Abstract
The ability of cultured peripheral-blood mononuclear cells (PBMC) to release interleukin-1 α and β (IL-1α, IL-1β) in response to concanavalin A (con A) was investigated in patients with chronic renal failure (CRF) and in renal transplant recipients. Mean IL-1α level released by PBMC of healthy subjects (n = 42), CRF patients (n = 42), or transplants 2 months after operation (n = 69) was 152 ± 103, 110 ± 80, or 154 ± 87 pg/5 × 105 cells/ml culture, respectively. IL-lα release from PBMC of recipients 2 months after renal transplantation was significantly higher than that of CRF patients (p 5 cells, respectively. Similar to IL-lα, the level in CRF was significantly lower than that in healthy subjects (pKeywords
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