Tests for Trends in Incidence Rate Ratios

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Abstract
Breslow (1984) described an efficient score test for trend in incidence density rate ratios for cohort studies under a conditional Poisson or binomial model employing maximum likelihood estimation of the rate parameters. In this communication, an alternative derivation of this statistic that is based on an unconditional approach is provided, along with an examination of associated goodness‐of‐fit tests and methods of confidence interval estimation. The procedures are illustrated by a cohort study of ischemic heart disease mortality following industrial exposure to carbon disulfide.

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