Repair in Mouse Lung after Split Doses of X Rays

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Abstract
A lung function assay in situ was used to investigate repair of X-ray injury in mice using 2 equal doses separated by 1, 7, or 28 days. Dose-response curves were obtained at 2-wk intervals up to 28 wk and at monthly intervals up to 48 wk. The D2-D1 values for early damage (radiation pneumonitis), i.e., 28 wk after the 2nd dose of radiation, were 3.95 (0-1 day), 4.80 (0-7 days) and 5.50 (0-28 days) Gy [gray]. These data agree well with repair values obtained from LD50 data from the same mice. The D2-D1 between 1 and 28 days was not as large (1.49-1.79 Gy) as that reported previously (3.60 Gy) by S.B. Field, S. Hornsey, and Y. Kutsutani (1976), it demonstrated significant slow repair. A clear dissociation of early pneumonitis and late fibrosis was observed in the mice, occurring only after the lowest total split dose given (19 Gy) and becoming more clearly dissociated as the time between the 2 doses was increased.

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