INVITRO INHIBITION OF PLATELET-AGGREGATION BY UREMIC MIDDLE MOLECULES

  • 1 January 1980
    • journal article
    • research article
    • Vol. 33  (6) , 185-188
Abstract
Uremic middle molecules were isolated from the urine of normal subjects and the blood in chronic renal insufficiency treated by hemodialysis. Their action was tested in vitro on platelets aggregation induced by ADP. Some fractions of these middle molecules (fractions 7b, 7c and 7fg) had no effect. The 7de fractions produced an inhibition of platelets aggregation. The percentage variations of 1st phase inhibition as a function of the middle molecules concentrations were studied.

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