Plasma protein binding, renal clearance, and pharmacokinetics of diuretics in rabbits.
- 1 January 1980
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 28 (8) , 2301-2308
- https://doi.org/10.1248/cpb.28.2301
Abstract
The transfer of 3 commercial diuretics (furosemide, bumetanide and hydroflumethiazide) in the biophase was investigated using rabbits. Pharmacokinetic analysis based on the 2 compartment open model was performed. The biological half-lives calculated from the .beta. phase of rabbit plasma level time courses were almost the same and were extremely short (20-40 min), in spite of the large differences among the 3 diuretics in plasma protein binding. Renal clearance experiments using rabbits indicated a large contribution of tubular secretion (.apprx. 80-90%). The plasma protein is involved in the transport of diuretics to the kidney.This publication has 1 reference indexed in Scilit:
- Binding of diuretics to human serum albumin and to human serum from healthy adults and patients with renal failure.CHEMICAL & PHARMACEUTICAL BULLETIN, 1979