AROMATIC RADIOFLUORINATION WITH [F-18] FLUORINE-GAS - 6-[F-18] FLUORO-L-DOPA

  • 1 January 1984
    • journal article
    • research article
    • Vol. 25  (11) , 1228-1233
Abstract
A new synthesis is described for the routine production of [18F]fluoro-L-dopa. The reaction between [18F] gas and L-dopa in liquid HF gave 2-, 5- and 6-[18F]fluoro-L-dopa. 6-[18F]Fluoro-L-dopa was isolated by reverse-phase high-pressure liquid chromatography. From 100 mCi [18F]F2, the method produces 3 mCi of 6-[18F]fluoro-L-dopa at the end of synthesis. [This research has application to human brain imaging.].

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