Lyophilization — a Means of Increasing Shelf-Life of Phospholipid Bi-Layer Vesicles

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Abstract
The release rates of sodium stibogluconate were followed in lyophilized and non-lyophilized phospholipid bi-layer vesicles. The release rates were followed under the following environmental temperatures: 4°C, 19°C, 29°C, 35°C, 45°C, 50°C and 55°C. Lyophilization did not significantly effect release rates within temperature groups 4°, 19°, 29°, 35 and 45°C. When the environmental temperature was varied above the tranisition temperature of the dipalmitoyl lecithin, release rates of sodium stibogluconate from lyophilized and non-lyophilized liposomes were found to be independent of temperature.

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