Relative sparing of nitric oxide synthase–containing neurons in the hippocampal formation in Alzheimer's disease
- 1 December 1992
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 32 (6) , 818-820
- https://doi.org/10.1002/ana.410320618
Abstract
Nitric oxide (NO) is an endogenous neuromodulator that may mediate neurotoxic effects of glutamate. NO-synthesizing neurons are, however, resistant to NO- and glutamate-induced neurotoxicity. We now show that NO synthase neurons are selectively spared in patients with Alzheimer's disease, even in a severely affected region of the brain such as the hippocampal formation.Keywords
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