Effect of 4-Amino-Pteroylglutamic Acid (Aminopterin) on Early Pregnancy.
- 1 May 1950
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 74 (1) , 204-208
- https://doi.org/10.3181/00379727-74-17855
Abstract
The effect of 4-amino-pteroylglutamic Acid (Aminopterin) on fetal development was studied using mature Sprague-Dawley and Wistar rats and CFW mice. The animals were injd. with 3 consecutive doses of 0.15 mg./kg. in mice and 0.1 or 0.15 mg./kg. in rats at intervals of either 12 or 24 hrs. The injns. were started from the 5th or 7th day after mating. Aminopterin was lethal to the early embryo of mice and rats. Fetal death was observed with doses which temporarily caused depletion of the bone marrow but no other significant signs of intoxication in mothers.Keywords
This publication has 3 references indexed in Scilit:
- Effects of 4-Amino-Pteroylglutamic Acid in Dogs with Special Reference to Megaloblastosis.Experimental Biology and Medicine, 1949
- Effect of Folic Acid, "4-Amino" Folic Acids and Related Substances on Growth of Chick Embryo.Experimental Biology and Medicine, 1949
- STUDIES OF THE ACTIONS OF 4-AMINO-PTEROYLGLUTAMIC ACID IN RATS AND MICE1949