Choline Stimulates Nicotinic Receptors on Adrenal Medullary Chromaffin Cells to Induce Catecholamine Secretion
- 23 October 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 214 (4519) , 466-468
- https://doi.org/10.1126/science.7291988
Abstract
Choline stimulated secretion of catecholamines from primary dissociated cultures of bovine adrenal medullary chromaffin cells by interacting with nicotinic receptors. Secretion was readily detected at a choline concentration of 1 millimole per liter and was maximal at 3 to 10 millimoles per liter; it was completely calcium-dependent. Further analysis suggested that choline acts as a partial nicotinic agonist.This publication has 25 references indexed in Scilit:
- Muscarinic Receptors in Chromaffin Cell Cultures Mediate Enhanced Phospholipid Labeling but Not Catecholamine SecretionJournal of Neurochemistry, 1981
- Regional CNS Levels of Acetylcholine and Choline During Hypoglycemic Stupor and RecoveryJournal of Neurochemistry, 1981
- Age-Related Changes in Passive Avoidance Retention: Modulation with Dietary CholineScience, 1980
- Pharmacological characterization of adrenal paraneurons: substance P and somatostatin as inhibitory modulators of the nicotinic responseBrain Research, 1979
- Neurotransmitter-related enzymes in senile dementia of the alzheimer typeBrain Research, 1979
- Pre- and postsynaptic neurochemical alterations in Alzheimer's diseaseBrain Research, 1978
- Choline in tardive dyskinesia and Huntington's diseaseLife Sciences, 1976
- Brain acetylcholine: Increase after systematic choline administrationLife Sciences, 1975
- A rapid radiochemical method for the determination of choline acetyltransferaseJournal of Neurochemistry, 1975
- Differential actions ofm and n cholinergic agonists on the brainstem activating systemInternational Journal of Neuropharmacology, 1969