Transmissible drug resistance in an epidemic strain ofSalmonella typhimurium

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Abstract
Among 309 cultures ofSalmonella typhimurium, phage-type 27, fifteen, isolated from eight patients, were found to be resistant to the three drugs, streptomycin, tetracycline and sulphathiazole. This triple resistance could be transferred by growth in mixed broth culture to a strain ofSkigella sonneiand back again to sensitive cultures ofS. typhimurium. In whole cultures the resistance was stable, but spontaneous loss could be demonstrated in a small proportion of the organisms in such cultures. No elimination of resistance was demonstrated after treatment with acriflavine. Resemblances to the multiple drug resistance in enteric bacteria reported from Japan are noted.The author is most grateful to Dr E. S. Anderson, Director of the Enteric Reference Laboratory, Colindale, N.W. 9, for phage-typing the cultures ofSalmonella typhimurium, and to Dr K. Patricia Carpenter, Director of the Dysentery Reference Laboratory, for supplying cultures ofSh. sonneiwhich were essential for the experimental work.