SURVIVAL AND REVIVAL OF NERVOUS TISSUES AFTER ARREST OF CIRCULATION

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Abstract
In work done variously on cats, rabbits, mice, rats, and guinea pigs, the cortical centers, palpebral-pupillary centers, the cardioregulatory center, the vasomotor center, and the respiratory center have been found to withstand complete anoxic anemia for periods of time that depend on the center, its state of activity, the age of the animal, the level of blood sugar, humoral and pharmacologic factors (insulin, vit. B, thiourea, thyroxin, adrenal cortical extract, Na pentobarbital, sulfanilamide, di-isopropylfluorophosphonate, monoiodoacetic acid), and certain disease conditions. Histological studies of the effects of cerebral anemia were made in man, monkeys, cats, dogs, guinea pigs. The duration of asphyxia necessary to abolish various activities dependent on the spinal cord has been studied in dogs, cats, and rabbits, and accompanied in some cases by histological observations. Synaptic function shows remarkable resistance to anemia. The excitability of peripheral nerve survives in anoxia longer than that of any other nervous tissue; it has been studied in man, as well as in frogs, rabbits, cats, and dogs; it varies with the size of fiber, length of nerve, and distance from the center.

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