Synthesis of analogues of the marine anti-tumour agent curacin A
- 1 January 1999
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 17,p. 2455-2460
- https://doi.org/10.1039/a904378k
Abstract
A concise, multigram synthesis of (4R)-2-[(1′R,2′S)-1′,2′-methano-3′-(tert-butyldiphenylsiloxy)propyl]-4-hydroxymethyl-4,5-dihydrothiazole has been achieved, and this compound has been used for the production of a range of analogues of the anti-mitotic agent curacin A.Keywords
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