Low Sensitivity of a Whole‐Blood Interferon‐γ Release Assay for Detection of Active Tuberculosis
Open Access
- 1 January 2007
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 44 (1) , 69-73
- https://doi.org/10.1086/509928
Abstract
The sensitivity of an interferon-γ assay (Quantiferon-TB Gold; Cellestis) was evaluated for the detection of tuberculosis among 242 persons with suspected tuberculosis in San Francisco, California. Thirty-seven subjects had culture-confirmed tuberculosis. Excluding 1 indeterminate result, 23 (64%; 95% confidence interval, 48%–78%) of 36 subjects had positive results using the QuantiFERON-TB Gold assay. The 64% sensitivity suggests that the QuantiFERON-TB Gold assay should not be used alone to exclude active tuberculosis.Keywords
This publication has 15 references indexed in Scilit:
- Sensitivity Analysis and Potential Uses of a Novel Gamma Interferon Release Assay for Diagnosis of TuberculosisJournal of Clinical Microbiology, 2006
- New tools and emerging technologies for the diagnosis of tuberculosis: Part I. Latent tuberculosisExpert Review of Molecular Diagnostics, 2006
- Comparison of two commercial interferon-γ assays for diagnosingMycobacterium tuberculosisinfectionEuropean Respiratory Journal, 2006
- Routine Hospital Use of a New Commercial Whole Blood Interferon-γ Assay for the Diagnosis of Tuberculosis InfectionAmerican Journal of Respiratory and Critical Care Medicine, 2005
- Discrepancy Between the Tuberculin Skin Test and the Whole-Blood Interferon γ Assay for the Diagnosis of Latent Tuberculosis Infection in an Intermediate Tuberculosis-Burden CountryJAMA, 2005
- Prospective Evaluation of a Whole-Blood Test Using Mycobacterium tuberculosis -Specific Antigens ESAT-6 and CFP-10 for Diagnosis of Active TuberculosisClinical and Vaccine Immunology, 2005
- Interferon-γ assays in the immunodiagnosis of tuberculosis: a systematic reviewThe Lancet Infectious Diseases, 2004
- Specific Detection of Tuberculosis InfectionAmerican Journal of Respiratory and Critical Care Medicine, 2004
- Diagnostic Standards and Classification of Tuberculosis in Adults and ChildrenAmerican Journal of Respiratory and Critical Care Medicine, 2000
- Two-sided confidence intervals for the single proportion: comparison of seven methodsStatistics in Medicine, 1998