CHANGES IN VOLUME AND VELOCITY OF BLOOD FLOW IN CHRONIC EXPERIMENTAL AORTIC REGURGITATION AND THE EFFECT OF CERTAIN DRUGS IN THIS CONDITION

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Abstract
Changes were found in relationships between cardiac output (F), stroke volume (SV), circulation times (lesser, greater and mean) and vol. of actively circulating blood in heart, lungs and great vessels (V). Animals (dogs) with lesions of varying severity were prepared and their responses to the lesion, to decompensating do.ses of adrenalin, and to vasodilator drugs were studied over a period of mos. The clinical picture of Corrigan''s disease was produced. The signs corresponded in intensity with degree of change as detd. by dye injection studies and with severity of lesion as found at autopsy. In most severe cases there was elec-trocardiographic evidence of myocardial damage and left ventricular preponderance, and in 1 case x-ray evidence of decided enlargement. The lesion decreased F, SV and V and increased heart rate, and ratio V/SV. These changes were in proportion to severity of the lesion, and with passage of time, tended to return toward normal by simple healing, by hypertrophy of the left ventricle or by hypertrophy with marked dilatation. In regurgitation, temporarily decompensating doses of epinephrine reduced F and SV to a greater degree than in the nor-mal; V increased, and absence of depressor reflex caused large immediate increase in heart rate, not seen in normal dog. Vasodilator drugs, nitrites and acetyl-[beta]-methyl-choline chloride caused increases in vol. and velocity flow, sometimes carrying above measurements and ratio V/SV to or beyond value before operation.

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