Synthesis of thiaprostaglandin E1 derivatives.
- 1 January 1985
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 33 (5) , 1815-1825
- https://doi.org/10.1248/cpb.33.1815
Abstract
A series of new thiaprostaglandins, 4-thia-, 5-thia-, 6-thia- and 7-thiaprostaglandin E1 methyl esters was synthesized by a 3-component coupling process using a chiral common synthon, (R)-4-tert-butyldimethylsilyloxy-2-cyclopentenone. Among these thiaprostaglandins, 7-thiaprostaglandin E1 methyl ester showed the most potent platelet aggregation-inhibiting activity.This publication has 6 references indexed in Scilit:
- Synthesis and rearrangement of 13-thiaprostanoidsTetrahedron, 1982
- Aggregation of platelets induced by novel synthetic secoprostaglandins.Journal of Pharmacobio-Dynamics, 1981
- A new synthesis of 3-oxocyclopentenesTetrahedron, 1978
- Prostaglandins and congeners. 16. Synthesis and bronchodilator activity of dl-11-deoxy-3-thiaprostaglandinsJournal of Medicinal Chemistry, 1977
- Prostaglandin chemistry—VIIITetrahedron, 1977
- Prostaglandin chemistry—VTetrahedron, 1976