Urinary Hydroxyproline and Plasma Mucoprotein as an Indication of the Presence of Bone Metastases

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Abstract
Total hydroxyproline excretion in urine, and mucoprotein, alkaline phosphatase activity and calcium contents of plasma were determined in 66 female patients with cancer. Significant increases in the hydroxyproline content of urine and the mucoprotein content of plasma have been found to be associated with the patients bearing advanced breast carcinomas with skeletal metastases. The urinary hydroxyproline excretions, unlike the plasma mucoprotein concentrations, were persistently increased even before the osseous deposits were radiologically demonstrable in the patients bearing early breast carcinoma. The present results, however, do not demonstrate any correlation between either the plasma alkaline phosphatase activity or the calcium levels and the extent of skeletal metastases.

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