MicroRNAs in cell proliferation, cell death, and tumorigenesis
Top Cited Papers
Open Access
- 21 February 2006
- journal article
- review article
- Published by Springer Nature in British Journal of Cancer
- Vol. 94 (6) , 776-780
- https://doi.org/10.1038/sj.bjc.6603023
Abstract
MicroRNAs (miRNAs) are a recently discovered class of ∼18–24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors.Keywords
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