Epithienamycins. II. Isolation and structure assignment.

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Abstract
At least 6 distinct .beta.-lactam antibiotics of the epithienamycin family are produced by a strain of Streptomyces flavogriseus MB 4638. Each of the 6 can be isolated in a substantially pure form by column chromatography using Dowex 1, Amberlite XAD-2 and Biogel packings. The structures were established by comparison of the UV, PMR and mass spectral characteristics with those of thienamycin and its derivatives. All 6 compounds contain the carbapenem ring system which is also found in thienamycin. They differ from each other and from thienamycin by chemical modifications and/or stereoisomerism. Enzymatically deacetylated epithienamycin A has the properties of an isomer of thienamycin.