Buspirone decreases the activity of 5-hydroxytryptamine-containing dorsal raphe neurons in-vitro
- 1 May 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 38 (5) , 380-382
- https://doi.org/10.1111/j.2042-7158.1986.tb04591.x
Abstract
Buspirone, a non-benzodiazepine anxiolytic agent, produced a dose-dependent decrease in the activity of 5-HT-containing dorsal raphe neurons recorded from mouse brain slices. The response was not changed in a low calcium/high magnesium incubation medium, indicating that the observed effects were the result of a direct action of buspirone on raphe neurons. These data are discussed within the context of the anxiolytic effects of buspirone.This publication has 17 references indexed in Scilit:
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