Defective thymine dimer excision by cell-free extracts of xeroderma pigmentosum cells.
- 1 August 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (8) , 2757-2761
- https://doi.org/10.1073/pnas.73.8.2757
Abstract
Crude extracts of normal human diploid fibroblasts and human peripheral blood lymphocytes excise thymine dimers from purified UV-irradiated DNA, or the DNA presumably present as chromatin in unfractionated cell free preparations of cells labeled with [3H]thymidine. Extracts of xeroderma pigmentosum cells from complementation groups A, C and D also excise thymine dimers from purified [Escherichia coli] DNA, but extracts of group A cells do not excise dimers from the DNA of radioactively labeled unfractionated cell-free preparations.Keywords
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