Effect of Thyroxine Administration on Enzymes Associated with Glucose Metabolism in the Liver.

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Abstract
Intraperitoneal injections of thyroxine in doses of 1 mg/rat/day for 5 days decreased liver fructose-1,6-disphosphatase activity of normal animals and showed no significant change in pyruvate kinase activity of thyroidectomized animal. Similar treatment increased glucose-6-phosphatase activity of both normal and thyroidectomized animals. Conditions which increase gluconeogenesis decrease pyruvate kinase activity and increase fructose-1,6-diphosphatase activity. These results suggest that increased glu-cose-6-phosphatase activity on thyroxine treatment is not related to gluconeogenesis.

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