Sex and age differences in the specific activity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase in human fetal kidney tissue

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Abstract
The specific activity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) was significantly greater (P < 0.005) in human kidney tissue obtained from male abortuses aged 10-16 wk after conception than in female abortuses of the same gestational age and in younger male and female abortuses. There was a significant correlation (r = 0.93, P < 0.001) between the specific activity of PGDH in fetal kidney and testicular tissues obtained from human abortuses of 10-26 wk gestational age. These results suggest a role for testosterone in the regulation of PGDH activity in the fetal kidney.