Suppression of Luteinizing Hormone and Testosterone Secretion in Bulls Following Adrenocorticotropin Hormone Treatment1

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Abstract
The present investigation was conducted to evaluate the inhibitory effects of adrenal corticosteroids on testosterone production by the bull testis. Administration of a single i.v. dose of ACTH (80 IU) resulted in a corticosteroid peak which lasted .apprx. 6 h. During this 6 h period, no episodic increases in secretion of LH [luteinizing hormone] or testosterone were initiated and basal concentrations of testosterone were suppressed (P < 0.05) below control values. Episodic secretion of LH and testosterone resumed 6-7 h after ACTH when concentrations of serum corticosteroids had returned to basal levels. Apparently, ACTH-induced increases in serum corticosteroids suppress the episodic secreiton of LH, resulting in a suppresion of testosterone secretion by the bull testis.

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