Characterisation of immunofluorescent heterophile antibodies which may be confused with autoantibodies.

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Abstract
Approximately 6% of [human] sera submitted for routine immunofluorescent autoantibody screening produced characteristic reaction patterns against a variety of animal [rat, mouse, guinea pig] and human tissues. These non-tissue-specific patterns probably represent a complex family of heterophile antibodies which could be confused with certain autoantibodies. These heterophile antibodies probably bear a relationship to Ig[immunoglobulin]G isohemagglutinins.