Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
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- 17 October 2010
- journal article
- Published by Springer Nature in Nature
- Vol. 468 (7320) , 117-121
- https://doi.org/10.1038/nature09464
Abstract
These authors identify the human enzyme responsible for menaquinone-4 biosynthesis, a naturally occurring form of vitamin K. They find that UbiA prenyltransferase containing 1, a human homologue of a prenyltransferase gene from Escherichia coli, encodes an enzyme that can convert vitamin K derivatives into menaquinone-4.Keywords
This publication has 27 references indexed in Scilit:
- Elucidation of the mechanism producing menaquinone-4 in osteoblastic cellsBioorganic & Medicinal Chemistry Letters, 2009
- Genetic analysis of 14 families with Schnyder crystalline corneal dystrophy reveals clues to UBIAD1 protein functionAmerican Journal of Medical Genetics Part A, 2008
- Metabolism and cell biology of vitamin KThrombosis and Haemostasis, 2008
- Vitamin K Induces Osteoblast Differentiation through Pregnane X Receptor-Mediated Transcriptional Control of the Msx2 GeneMolecular and Cellular Biology, 2007
- Mutations in theUBIAD1Gene on Chromosome Short Arm 1, Region 36, Cause Schnyder Crystalline Corneal DystrophyInvestigative Opthalmology & Visual Science, 2007
- Mutations in the UBIAD1 Gene, Encoding a Potential Prenyltransferase, Are Causal for Schnyder Crystalline Corneal DystrophyPLOS ONE, 2007
- Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesisHuman Molecular Genetics, 2007
- Steroid and Xenobiotic Receptor SXR Mediates Vitamin K2-activated Transcription of Extracellular Matrix-related Genes and Collagen Accumulation in Osteoblastic Cells*Journal of Biological Chemistry, 2006
- Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the ratBiochimica et Biophysica Acta (BBA) - General Subjects, 1998
- Vitamin K status in human tissues: tissue-specific accumulation of phylloquinone and menaquinone-4British Journal of Nutrition, 1996