Biochemical Studies of Pigments from the Pathogenic Fungus, Microsporum cookei
- 1 October 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 74 (4) , 805-810
- https://doi.org/10.1093/oxfordjournals.jbchem.a130306
Abstract
Some effects of a naphthoquinone pigment, xanthomegnin, isolated from Microsporum cookei on rat liver mitochondria were examined. 1. Polarographic monitoring of O2 consumption indicated that xanthomegnin is a strong uncoupler of oxidative phosphorylation in rat liver mitochondria. 2. The latent adenosinetriphosphatase [ATPase, EC 3.6.1.3] activity of freshly prepared mitochondria was markedly stimulated by xanthomegnin; this stimulation was prevented by bovine serum albumin (BSA). 3. A large-amplitude swelling of isolated mitochondria was induced by xanthomegnin in isotonic KCl; addition of BSA suppressed this induction of mitochondrial swelling.Keywords
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