Nutritional significance of cyclodextrins: Indigestibility and hypolipemic effect of .ALPHA.-cyclodextrin.

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Abstract
Digestibility of .alpha.- and .beta.-cyclodextrin (cD) and nutritional consequences of .alpha.-CD and a CD mixture (n-dextrin, .alpha.-, .beta.- and .gamma.-CD = 50, 30, 15 and 5% by wt) were investigated in rats. In contrast with .beta.-CD, .alpha.-CD was indigestible. Growing rats were fed on diets supplemented with the CD mixture at 19.5, 39, 58.5 and 78% levels for 110 days, resulting in smaller wt gain and body fat deposition when they were fed on a higher CD diet. Rats of wt loss during the restricted feeding were faster in rats fed on a higher CD diet. These were due to food efficiency lowered by CD. Reduced serum and liver triacylglycerol (TG) levels were noted during a 110-day period of feeding of the CD diets; the former was revealed due to a reduced hepatic-intestinal TG secretion rate. Rats fed on a 78% CD diet, which contained .alpha.-CD at the 24% level, showed abnormal symptoms such as poor appetite and constipation with gas accumulation in the large intestine. Some of them died during the first 2-wk feeding period. The surviving animals showed adaptation to the diet in the later period of the 110-day feeding. .alpha.-CD may evidently be classified as dietary fiber which can modulate lipid metabolism in rats. The CD mixture may be available as a calorie substitute for wt control, which may owe mostly to .alpha.-CD.

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