Fatal Massive Necrosis of the Liver as a Manifestation of Hypersensitivity to Probenecid

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Abstract
PROBENECID∥ was introduced in 1949 as an agent that would inhibit the renal tubular secretion of penicillin.1 Other uses were soon found, and probenecid is widely used for its uricosuric effect in chronic gout and gouty arthritis. In 1955 Boger and Strickland2 reviewed the side effects of probenecid as observed in over 2500 patients and reported no fatal reactions. The case described below is reported because it is interpreted as a fatal reaction to probenecid with the major lesion consisting of massive necrosis of the liver. The validity of this assumption will become apparent from a review of the time . . .

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