Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes
- 1 February 1977
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 265 (5593) , 421-424
- https://doi.org/10.1038/265421a0
Abstract
The culture lifetime of epidermal cells of newborn humans is increased from 50 to 150 generations by adding to the medium epidermal growth factor [EGF], a polypeptide mitogen. EGF seems to delay senescence of the cells by maintaining them in a state further removed from terminal differentiation. This effect is revealed by a greater ability of the cells to survive subculture and initiate new colonies, but not necessarily by an increased growth rate.This publication has 25 references indexed in Scilit:
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