Ocular effects of two different prostaglandin F2α esters

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Abstract
Ocular hypotensive effects and side effects of two different topically prostaglandin (PG) esters were evaluated in a double masked study in 12 healthy males. Three doses of 15-propionat-PGF2.alpha.-isopropylester (15-prop-PGF2.alpha.-IE), two doses of PGF2.alpha.-isopropylester (PGF2.alpha.-IE), and placebo were compared. At equipotent doses 15-prop-PGF2.alpha.-IE caused similar ocular side effects as PGF2.alpha.-IE. It is concluded that both PGF2.alpha.-IE and 15-prop-PGF2.alpha.-IE reduce the IOP in normal eyes, but the use of a diester such as 15-prop-PGF2.alpha.-IE does not provide a better separation between effect on IOP and side effects than PGF2.alpha.-IE.