In vitro Studies of the Mechanism of Polyuria Induced by Dextro Propoxyphene (Darvon).

1 October 1965

journal article
research article
Published by Frontiers Media SA in Experimental Biology and Medicine

Vol. 120 (1) , 155-157
https://doi.org/10.3181/00379727-120-30472

Abstract

Summary The isolated surviving toad bladder was used to demonstrate direct peripheral antagonism between antidiuretic hormone and both dextro propoxyphene (Darvon®) and levo propoxyphene (Norvad®). These findings suggest that the polyuria accompanying a recent death after dextro propoxyphene ingestion was a result of drug-induced nephrogenic diabetes insipidus.