Gene for α-Chain of Human T-Cell Receptor: Location on Chromosome 14 Region Involved in T-Cell Neoplasms

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Abstract
A human complementary DNA clone specific for the α-chain of the T-cell receptor and a panel of rodent × human somatic cell hybrids were used to map the α-chain gene to human chromosome 14 in a region proximal to the immunoglobulin heavy chain locus. Analysis by means of in situ hybridization of human metaphase chromosomes served to further localize the α-chain gene to region 14q11-q12, which is consistently involved in translocations and inversions detectable in human T-cell leukemias and lymphomas. Thus, the locus for the α-chain T-cell receptor may participate in oncogene activation in T-cell tumors.