KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M-Channel
- 4 December 1998
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 282 (5395) , 1890-1893
- https://doi.org/10.1126/science.282.5395.1890
Abstract
The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.Keywords
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