Carbamazepine for epilepsy

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Abstract
The efficacy, bioavailability, and tolerance of carbamazepine in epilepsy were evaluated in a prospective, double-blind study. The study was made in 45 institutionalized patients whose seizures were not controlled completely by combinations of currently available an-tiepileptic drugs in adequate dosages as determined by serum concentrations. In this population, carbamazepine was equal in efficacy to phenobarbital or diphenylhydantoin in controlling seizure frequency, and side effects were minimal. Serum concentrations of carbamazepine were measured up to 13.7 rncg per milliliter, with 70 percent of the values ranging from 5 to 10 mcg per milliliter. Individual episodes of transient leukopenia occurred during the 21-day lest period, but a statistically significant incidence of leukopenia was not observed.

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