Susceptibility of Lewis Rats to Experimental Autoimmune Encephalomyelitis After Recovery from Passively Induced Disease
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in Immunological Communications
- Vol. 9 (4) , 333-340
- https://doi.org/10.3109/08820138009052980
Abstract
Experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats by adoptive transfer of 5 × 107 sensitized syngeneic lymphoid cells from donors challenged 12 to 43 days earlier with myelin basic protein and complete Freund's adjuvant. The donor cells were cultured for 72 hours with antigen prior to transfer. Following recovery, the recipients remained susceptible to EAE induced by challenge with antigen and adjuvant. The relevance of this finding to host recovery mechanisms is discussed.This publication has 13 references indexed in Scilit:
- Experimental Allergic Encephalomyelitis: Enhancement of Cell-Mediated Transfer by Concanavalin AThe Journal of Immunology, 1977
- Characterization of suppressor cells involved in regulation of experimental allergic encephalomyelitisEuropean Journal of Immunology, 1976
- Brain Vascular Permeability to I125Gamma Globulin and Leukocytes in Allergic Encephalomyelitis*†Journal of Neuropathology and Experimental Neurology, 1967