The Hematopoietic Microenvironment

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Abstract
IN this issue of the Journal, Ershler et al. present the most compelling evidence to date for the existence of a naturally occurring human disease of the hematopoietic microenvironment. Their patient had long-standing and probably congenital anemia due to failure of maturation of erythroid precursors in the marrow. However, when her marrow cells were aspirated and dispersed in culture systems, erythroid precursors proved to be abundant, and they matured and synthesized heme. Conversely, a nondispersed section of marrow obtained by means of biopsy failed to synthesize heme when placed in culture, although a similar sample of marrow from a . . .