Molecular Signatures of Natural Selection
Top Cited Papers
- 1 December 2005
- journal article
- review article
- Published by Annual Reviews in Annual Review of Genetics
- Vol. 39 (1) , 197-218
- https://doi.org/10.1146/annurev.genet.39.073003.112420
Abstract
There is an increasing interest in detecting genes, or genomic regions, that have been targeted by natural selection. The interest stems from a basic desire to learn more about evolutionary processes in humans and other organisms, and from the realization that inferences regarding selection may provide important functional information. This review provides a nonmathematical description of the issues involved in detecting selection from DNA sequences and SNP data and is intended for readers who are not familiar with population genetic theory. Particular attention is placed on issues relating to the analysis of large-scale genomic data sets.Keywords
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