Design and inhibitory properties of synthetic Bowman‐Birk loops
- 1 August 1992
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 40 (2) , 97-102
- https://doi.org/10.1111/j.1399-3011.1992.tb01455.x
Abstract
A cyclic tridecapeptide based on the sequence of an anti-tryptic loop of a Bowman-Birk inhibitor was synthesized, and demonstrated to be active as an inhibitor of trypsin. Molecular modeling of this sequence suggested an improved sequence which demonstrated an order of magnitude improvement in the inhibitory constant.Keywords
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