Effects of Lecithin, Cholesterol, and Serum on Erythrocyte Modification and Antibody Neutralization by Enterobacterial Lipopolysaccharides.

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Abstract
Sheep red blood cells treated with mixtures of purified enterobacterial (Escherichia coli 08 or Salmonella abortus equi) lipopolysaccharides and lecithin, cholesterol, or normal serum were not agglutinated by homologous bacterial antibodies. Pretreatment of erythrocytes with lecithin but not with cholesterol or compatible normal serum had similar effects. The antibody-neutralizing capacity of the lipopolysaccharide-inhibitor mixtures was identical with that of the lipopolysaccharides, as revealed by hemagglutination-inhibition tests. It is concluded that the inhibitors interfere with adsorption of enterobacterial lipopolysaccharides by erythrocytes.