Pulmonary Vascular Resistance in Anesthetised Dogs

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Abstract
Pulmonary vein pressure was elevated in intact anesthetized dogs by either prolonged inspiratory airway resistance breathing, expiratory airway resistance breathing or increased intracranial pressure. Under the conditions studied, the pulmonary vascular pressure gradient decreased significantly whereas cardiac output remained essentially unchanged. Pulmonary vascular resistance as calculated decreased as pulmonary vein pressure was elevated. The data indicate that the absolute level of intraluminal pressure over external pressure is an important factor in determining pulmonary vessel diameter and hence resistance.