REQUIREMENT OF MACROPHAGE METABOLIC-ACTIVITY FOR LYMPHOCYTE-T ACTIVATION

  • 1 January 1982
    • journal article
    • research article
    • Vol. 38  (1) , 1-4
Abstract
Macrophages are necessary accessory cells for T-lymphocyte activation by antigens, mitogens and allogenic cells. The function of metabolically inactive macrophages in the activation of [mouse] T-lymphocytes by phytohemagglutinin (PHA) was studied. Macrophages inactivated by mitomycin C are unable to collaborate with T-lymphocytes in the development of the proliferative response to PHA indicating that the role of the macrophage in T-lymphocyte activation by mitogens goes beyond in solubilizing it or rendering it more stimulatory by another passive mechanism.